Pluckeye can allow or block programs by filename, absolute path, or directory.

pluck + allow program foo.exe
pluck + allow program:C:\Windows\System32\notepad.exe
pluck + allow program /usr/bin/env

To allow a program only for a specific user,

pluck + allow user jane program foo.exe

To allow a program only during specific times, use when.

pluck + when 11-12 allow program foo.exe

To allow a program only during specific times by a specific user,

pluck + when 11-12 allow user jane program foo.exe